Analytical Data
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Gene name
PLA1A
- Application
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Alternative Names
PLA1A;NMD;PSPLA1;Phospholipase A1 member A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q53H76
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Expression Region
26-456aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSDAPPTPQ PKCADFQSAN LFEGTDLKVQ FLLFVPSNPS CGQLVEGSSD LQNSGFNATL GTKLIIHGFR VLGTKPSWID TFIRTLLRAT NANVIAVDWI YGSTGVYFSA VKNVIKLSLE ISLFLNKLLV LGVSESSIHI IGVSLGAHVG GMVGQLFGGQ LGQITGLDPA GPEYTRASVE ERLDAGDALF VEAIHTDTDN LGIRIPVGHV DYFVNGGQDQ PGCPTFFYAG YSYLICDHMR AVHLYISALE NSCPLMAFPC ASYKAFLAGR CLDCFNPFLL SCPRIGLVEQ GGVKIEPLPK EVKVYLLTTS SAPYCMHHSL VEFHLKELRN KDTNIEVTFL SSNITSSSKI TIPKQQRYGK GIIAHATPQC QINQVKFKFQ SSNRVWKKDR TTIIGKFCTA LLPVNDREKM VCLPEPVNLQ ASVTVSCDLK IACV
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Molecular Weight
50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLA1A (phospholipase A1 member A) is an enzyme involved in the hydrolysis of phospholipids, playing a crucial role in various biological processes, including membrane remodeling, inflammation, and lipid metabolism. Recent studies have highlighted its significance in health and disease, particularly in relation to cardiovascular diseases and certain types of cancer. The investigation of PLA1A has gained momentum due to its potential as a therapeutic target and a biomarker for monitoring disease progression. Recombination technology allows for the efficient production of PLA1A as a recombinant protein, enabling detailed studies of its structure, function, and interactions with other biomolecules. By generating high-purity PLA1A, researchers can elucidate its enzymatic mechanisms and assess how its activity is regulated in physiological and pathological contexts. Furthermore, understanding the role of PLA1A in lipid signaling pathways may offer insights into novel treatment strategies aimed at modulating its activity for therapeutic benefits. As more is discovered about PLA1A’s biological functions, the development of PLA1A-targeted therapies could pave the way for innovative interventions in diseases linked to phospholipid metabolism. This underscores the importance of continued research on recombinant PLA1A to unlock its full potential in biomedical applications.
