Analytical Data
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基因名
METT10D
- Application
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别名
METTL16; METT10D; RNA N6-adenosine-methyltransferase METTL16; Methyltransferase 10 domain-containing protein; Methyltransferase-like protein 16; N6-adenosine-methyltransferase METTL16; EC 2.1.1.348; U6 small nuclear RNA; adenine-(43)-N(6))-methyltransferase; EC 2.1.1.346
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86W50
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表达区间
1-562 aa
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氨基酸序列
MALSKSMHAR NRYKDKPPDF AYLASKYPDF KQHVQINLNG RVSLNFKDPE AVRALTCTLL REDFGLSIDI PLERLIPTVP LRLNYIHWVE DLIGHQDSDK STLRRGIDIG TGASCIYPLL GATLNGWYFL ATEVDDMCFN YAKKNVEQNN LSDLIKVVKV PQKTLLMDAL KEESEIIYDF CMCNPPFFAN QLEAKGVNSR NPRRPPPSSV NTGGITEIMA EGGELEFVKR IIHDSLQLKK RLRWYSCMLG KKCSLAPLKE ELRIQGVPKV TYTEFCQGRT MRWALAWSFY DDVTVPSPPS KRRKLEKPRK PITFVVLASV MKELSLKASP LRSETAEGIV VVTTWIEKIL TDLKVQHKRV PCGKEEVSLF LTAIENSWIH LRRKKRERVR QLREVPRAPE DVIQALEEKK PTPKESGNSQ ELARGPQERT PCGPALREGE AAAVEGPCPS QESLSQEENP EPTEDERSEE KGGVEVLESC QGSSNGAQDQ EASEQFGSPV AERGKRLPGV AGQYLFKCLI NVKKEVDDAL VEMHWVEGQN RDLMNQLCTY IRNQIFRLVA VN
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分子量
63,6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
METT10D is a member of the Methyltransferase family, recognized for its role in the post-translational modification of proteins through methylation, a critical process that influences various cellular functions and signal transduction pathways. Recent studies have highlighted its significance in modulating gene expression and regulating cellular responses, making it an intriguing target for understanding the mechanisms of gene regulation and potential therapeutic interventions. The research surrounding METT10D focuses on elucidating its structure-function relationship, particularly its enzymatic activity and substrate specificity, to determine how it contributes to cellular homeostasis and pathology. Notably, alterations in the expression or activity of methyltransferases, including METT10D, have been implicated in various diseases, including cancer and neurodegenerative disorders. Therefore, investigating METT10D through recombinant protein techniques offers promising insights into its biological roles and could pave the way for the development of novel therapeutic strategies aimed at modulating its activity for disease intervention. As such, METT10D stands at the intersection of protein chemistry, molecular biology, and therapeutic development, making it a compelling subject of ongoing research in biological and medical sciences.
