Analytical Data
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基因名
COL6
- Application
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别名
COL6；Collagen alpha-1(XIX) chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8LG76
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表达区间
1-406aa
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氨基酸序列
MMKSLASAVG GKTARACDSC VKRRARWYCA ADDAFLCHAC DGSVHSANPL ARRHERVRLK SASAGKYRHA SPPHQATWHQ GFTRKARTPR GGKKSHTMVF HDLVPEMSTE DQAESYEVEE QLIFEVPVMN SMVEEQCFNQ SLEKQNEFPM MPLSFKSSDE EDDDNAESCL NGLFPTDMEL AQFTADVETL LGGGDREFHS IEELGLGEML KIEKEEVEEE GVVTREVHDQ DEGDETSPFE ISFDYEYTHK TTFDEGEEDE KEDVMKNVME MGVNEMSGGI KEEKKEKALM LRLDYESVIS TWGGQGIPWT ARVPSEIDLD MVCFPTHTMG ESGAEAHHHN HFRGLGLHLG DAGDGGREAR VSRYREKRRT RLFSKKIRYE VRKLNAEKRP RMKGRFVKRS SIGVAH
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分子量
46 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Collagen type VI (COL6) is a crucial extracellular matrix protein that plays significant roles in tissue structure, stability, and cellular interactions. It is primarily found in connective tissues and is known for its role in maintaining tissue integrity and facilitating cell adhesion and migration. Mutations in the genes encoding COL6 can lead to various dystrophic conditions, such as Bethlem myopathy and Ullrich congenital muscular dystrophy. Research into COL6 has gained momentum due to its involvement in muscle diseases and potential implications for regenerative medicine. Scientists are exploring recombinant COL6 proteins for therapeutic purposes, aiming to understand their functional properties and interactions at the molecular level. Furthermore, these studies are crucial for developing treatment strategies that may alleviate muscle degeneration and other related disorders. Recombinant COL6 proteins provide a valuable tool for elucidating the mechanisms of COL6-related diseases and potentially offer therapeutic avenues for restoring tissue function. Understanding COL6’s structure and function is vital for advancing tissue engineering applications and developing novel biomarkers for diagnosing collagen-related pathologies.
