Analytical Data
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Gene name
PECI
- Application
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Alternative Names
ECI2;DRS1;HCA88;PECI;Enoyl-CoA delta isomerase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75521
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Expression Region
31-394aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMNRTAMRASQKDFENSMNQVKLLKKDPGNE VKLKLYALYKQATEGPCNMPKPGVFDLINKAKWDAWNALGSLPKEAARQN YVDLVSSLSPSLESSSQVEPGTDRKSTGFETLVVTSEDGITKIMFNRPKK KNAINTEMYHEIMRALKAASKDDSIITVLTGNGDYYSSGNDLTNFTDIPP GGVEEKAKNNAVLLREFVGCFIDFPKPLIAVVNGPAVGISVTLLGLFDAV YASDRATFHTPFSHLGQSPEGCSSYTFPKIMSPAKATEMLIFGKKLTAGE ACAQGLVTEVFPDSTFQKEVWTRLKAFAKLPPNALRISKEVIRKREREKL HAVNAEECNVLQGRWLSDECTNAVVNFLSRKSKL
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Molecular Weight
42 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PECI (Peroxisomal Enzyme Catalase-Inducing Protein) is a novel protein that has garnered attention in the field of cellular biology and biochemistry due to its role in regulating peroxisomal enzyme activity and its potential implications in disease mechanisms. Research into PECI has revealed its involvement in the oxidative stress response, which is crucial for cell survival and function, especially in conditions associated with high levels of reactive oxygen species (ROS). As oxidative stress is linked to various pathologies, including neurodegenerative diseases, cancer, and metabolic disorders, understanding the molecular mechanisms and regulatory pathways involving PECI becomes essential. Studies have indicated that PECI can modulate the expression of catalase, an enzyme that protects cells from oxidative damage, thereby suggesting its potential as a therapeutic target. Furthermore, the exploration of PECI's interactions with other cellular components and signaling pathways may provide insights into its broader biological functions and its potential applications in enhancing cellular resilience against stressors. Overall, the investigation of PECI not only contributes to a deeper understanding of peroxisomal function and homeostasis but also opens new avenues for developing strategies to mitigate oxidative damage in various clinical contexts.
