Analytical Data
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Gene name
MAP1B
- Application
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Alternative Names
MAP1B；Microtubule-associated Protein 1B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P46821
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
270.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP1B, or Microtubule-Associated Protein 1B, is a crucial protein involved in the regulation of microtubule dynamics and neuronal development. It plays a significant role in various cellular processes, including axon growth, synaptogenesis, and maintaining neuronal integrity. Research on MAP1B has gained momentum due to its implications in neurodevelopmental disorders and neurodegenerative diseases. Dysregulation of MAP1B expression or function has been linked to conditions such as Alzheimer’s disease, schizophrenia, and other cognitive disorders. Understanding the structure and function of MAP1B, particularly through the study of recombinant MAP1B proteins, allows researchers to dissect its interactions with microtubules and other cellular components. This can provide insights into the molecular mechanisms underlying its role in neuronal health and disease. Moreover, recombinant MAP1B proteins serve as valuable tools in studying therapeutic strategies aimed at modulating microtubule dynamics and enhancing neuronal repair processes. By elucidating the pathways influenced by MAP1B, scientists aim to develop novel interventions for brain disorders characterized by synaptic dysfunction and impaired neurodevelopment. In summary, the exploration of MAP1B through recombinant protein studies is critical for advancing our knowledge of neuronal function and potential therapeutic approaches for neurodegenerative diseases.
