Analytical Data
-
Gene name
MCRS1
- Application
-
Alternative Names
58 kDa microspherule protein; Cell cycle regulated factor (78 kDa); Cell cycle regulated factor p78; Cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit J; MCRS 1; MCRS 2; MCRS1; MCRS1_HUMAN; MCRS2; Microspherule protein 1; MSP 58; MSP58; p78
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q96EZ8
-
Expression Region
1-462aa
-
AA Sequence
MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR FIKRKKFDDE LVESSLAKSS TRAKGASGVE PGRCSGSEPS SSEKKKVSKA PSTPVPPSPA PAPGLTKRVK KSKQPLQVTK DLGRWKPADD LLLINAVLQT NDLTSVHLGV KFSCRFTLRE VQERWYALLY DPVISKLACQ AMRQLHPEAI AAIQSKALFS KAEEQLLSKV GSTSQPTLET FQDLLHRHPD AFYLARTAKA LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV LEHELMVADR RQKREIRQLE QELHKWQVLV DSITGMSSPD FDNQTLAVLR GRMVRYLMRS REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG DFFIANEGRR PIYIDGRPVL CGSKWRLSNN SVVEIASLRF VFLINQDLIA LIRAEAAKIT PQ
-
Molecular Weight
51,8 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MCRS1 (Mediator of DNA Damage Checkpoint 1) is a crucial protein involved in the cellular response to DNA damage, playing a significant role in maintaining genomic stability. As a member of the MCRS family, MCRS1 is implicated in various cellular processes, including DNA repair, cell cycle regulation, and transcriptional control. Research has shown that MCRS1 interacts with key proteins involved in DNA damage response pathways, thus facilitating the repair mechanisms necessary for cellular survival under genotoxic stress. Its dysfunction or altered expression has been associated with several pathologies, including cancer, highlighting its importance in tumorigenesis and progression. The study of recombinant MCRS1 proteins has gained traction in recent years, as it allows researchers to dissect the structure-function relationships and interaction networks of this protein. By expressing MCRS1 in a recombinant system, scientists can produce purified proteins that are vital for biochemical assays, structural analyses, and functional studies. Understanding the molecular mechanisms by which MCRS1 modulates DNA damage responses can provide insights into potential therapeutic targets for cancer treatments, as well as contribute to the broader field of DNA repair and cellular resilience against stress. Such research endeavors aim to further clarify MCRS1's role in health and disease and exploit its functionality in biotechnological applications or novel drug development. As the field progresses, the production and study of recombinant MCRS1 is poised to reveal new dimensions of its biological significance and open avenues for targeted interventions in disease contexts where DNA damage response pathways are compromised.
