Analytical Data
-
基因名
MCRS1
- Application
-
别名
58 kDa microspherule protein; Cell cycle regulated factor (78 kDa); Cell cycle regulated factor p78; Cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit J; MCRS 1; MCRS 2; MCRS1; MCRS1_HUMAN; MCRS2; Microspherule protein 1; MSP 58; MSP58; p78
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q96EZ8
-
表达区间
1-462aa
-
氨基酸序列
MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR FIKRKKFDDE LVESSLAKSS TRAKGASGVE PGRCSGSEPS SSEKKKVSKA PSTPVPPSPA PAPGLTKRVK KSKQPLQVTK DLGRWKPADD LLLINAVLQT NDLTSVHLGV KFSCRFTLRE VQERWYALLY DPVISKLACQ AMRQLHPEAI AAIQSKALFS KAEEQLLSKV GSTSQPTLET FQDLLHRHPD AFYLARTAKA LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV LEHELMVADR RQKREIRQLE QELHKWQVLV DSITGMSSPD FDNQTLAVLR GRMVRYLMRS REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG DFFIANEGRR PIYIDGRPVL CGSKWRLSNN SVVEIASLRF VFLINQDLIA LIRAEAAKIT PQ
-
分子量
51,8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MCRS1 (Mediator of DNA Damage Checkpoint 1) is a crucial protein involved in the cellular response to DNA damage, playing a significant role in maintaining genomic stability. As a member of the MCRS family, MCRS1 is implicated in various cellular processes, including DNA repair, cell cycle regulation, and transcriptional control. Research has shown that MCRS1 interacts with key proteins involved in DNA damage response pathways, thus facilitating the repair mechanisms necessary for cellular survival under genotoxic stress. Its dysfunction or altered expression has been associated with several pathologies, including cancer, highlighting its importance in tumorigenesis and progression. The study of recombinant MCRS1 proteins has gained traction in recent years, as it allows researchers to dissect the structure-function relationships and interaction networks of this protein. By expressing MCRS1 in a recombinant system, scientists can produce purified proteins that are vital for biochemical assays, structural analyses, and functional studies. Understanding the molecular mechanisms by which MCRS1 modulates DNA damage responses can provide insights into potential therapeutic targets for cancer treatments, as well as contribute to the broader field of DNA repair and cellular resilience against stress. Such research endeavors aim to further clarify MCRS1's role in health and disease and exploit its functionality in biotechnological applications or novel drug development. As the field progresses, the production and study of recombinant MCRS1 is poised to reveal new dimensions of its biological significance and open avenues for targeted interventions in disease contexts where DNA damage response pathways are compromised.
