Analytical Data
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基因名
MBNL2
- Application
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别名
DKFZp781H1296; MBLL; MBLL39; Mbnl2; MBNL2_HUMAN; MGC120625; MGC120626; MGC120628; Muscleblind like 2; muscleblind like protein 1; muscleblind like protein 2; muscleblind like protein like 39; muscleblind like splicing regulator 2; Muscleblind-like protein 1; Muscleblind-like protein 2; Muscleblind-like protein-like 39
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5VZF2
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表达区间
1-373aa
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氨基酸序列
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPAIGTNTAISFAPYLAPVTPGVGLVPTEILPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTSDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMAFPPGALHPLPKRQALEKSNGTSAVFNPSVLHYQQALTSAQLQQHAAFIPTGSVLCMTPATSIDNSEIISRNGMECQESALRITKHCYCTYYPVSSSIELPQTAC
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分子量
66.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MBNL2 (Muscleblind-like 2) is a member of the MBNL family of RNA-binding proteins that play critical roles in the regulation of gene expression at the post-transcriptional level. Research into MBNL2 has gained significant interest due to its involvement in various physiological processes and its association with several diseases, including myotonic dystrophy, a genetic disorder characterized by muscular and systemic impairment. The protein is known to participate in alternative splicing, RNA stability, and localization, influencing the expression of genes vital for muscle function and repair. Disruptions in MBNL2 function can lead to misregulation of target pre-mRNAs, contributing to the pathophysiology observed in myotonic dystrophy. Consequently, studying the functional properties, interactions, and expression dynamics of MBNL2, particularly through the development of recombinant proteins, provides essential insights into its biological roles and potential therapeutic targets. Recombinant studies enable researchers to dissect MBNL2's mechanisms and interactions at a molecular level, potentially paving the way for novel strategies to mitigate or correct the dysregulation associated with diseases. Thus, characterizing MBNL2 as a recombinant protein emerges as a significant focus in molecular biology and therapeutic research, offering hope for advancements in understanding RNA regulatory networks and addressing related disorders.
