Analytical Data
-
Gene name
MBNL2
- Application
-
Alternative Names
DKFZp781H1296; MBLL; MBLL39; Mbnl2; MBNL2_HUMAN; MGC120625; MGC120626; MGC120628; Muscleblind like 2; muscleblind like protein 1; muscleblind like protein 2; muscleblind like protein like 39; muscleblind like splicing regulator 2; Muscleblind-like protein 1; Muscleblind-like protein 2; Muscleblind-like protein-like 39
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q5VZF2
-
Expression Region
1-373aa
-
AA Sequence
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPAIGTNTAISFAPYLAPVTPGVGLVPTEILPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTSDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMAFPPGALHPLPKRQALEKSNGTSAVFNPSVLHYQQALTSAQLQQHAAFIPTGSVLCMTPATSIDNSEIISRNGMECQESALRITKHCYCTYYPVSSSIELPQTAC
-
Molecular Weight
66.9 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MBNL2 (Muscleblind-like 2) is a member of the MBNL family of RNA-binding proteins that play critical roles in the regulation of gene expression at the post-transcriptional level. Research into MBNL2 has gained significant interest due to its involvement in various physiological processes and its association with several diseases, including myotonic dystrophy, a genetic disorder characterized by muscular and systemic impairment. The protein is known to participate in alternative splicing, RNA stability, and localization, influencing the expression of genes vital for muscle function and repair. Disruptions in MBNL2 function can lead to misregulation of target pre-mRNAs, contributing to the pathophysiology observed in myotonic dystrophy. Consequently, studying the functional properties, interactions, and expression dynamics of MBNL2, particularly through the development of recombinant proteins, provides essential insights into its biological roles and potential therapeutic targets. Recombinant studies enable researchers to dissect MBNL2's mechanisms and interactions at a molecular level, potentially paving the way for novel strategies to mitigate or correct the dysregulation associated with diseases. Thus, characterizing MBNL2 as a recombinant protein emerges as a significant focus in molecular biology and therapeutic research, offering hope for advancements in understanding RNA regulatory networks and addressing related disorders.
