Analytical Data
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Gene name
LONRF2
- Application
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Alternative Names
LONRF2; RNF192; LON peptidase N-terminal domain and RING finger protein 2; Neuroblastoma apoptosis-related protease; RING finger protein 192
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q1L5Z9
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Expression Region
1-754aa
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AA Sequence
MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML AGLAQPDRGL CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG GLVRAVGLRD RPLSAENPGG EPEAPGEGGP APEPRAPRDL LGCPRCRRLL HKPVTLPCGL TVCKRCVEPG PARPQVRRVN VVLSGLLEKC FPAECRLRRL AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL YLTMKNYEQA LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD AGSSENSSEK SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK RQFPDDVEDA PDLNAPGKIP KKDLSLQRSP NSETEESQGL SLDVTDFECA LCMRLLFEPV TTPCGHTFCL KCLERCLDHA PHCPLCKDKL SELLASRNFN ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI FVCAMAFPTV PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA ALHDSVHQQS VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW WILAVLPLER KAQLAILGMT SLKERLLAIR RILVIITRKM NSRQELANAR ERNN
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Molecular Weight
83.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LONRF2, or Lon peptidase-like protein 2, is a member of the Lon protease family, which plays a critical role in mitochondrial quality control, protein degradation, and cellular homeostasis. Research on LONRF2 has gained traction due to its potential involvement in various diseases, including neurodegenerative disorders and cancer. The protein is believed to contribute to mitochondrial dynamics and function, acting as a chaperone to assist in the correct folding and assembly of mitochondrial proteins. Aberrations in LONRF2 expression or function can lead to mitochondrial dysfunction, characterized by increased oxidative stress and impaired ATP production, thereby affecting overall cellular health. Additionally, the protein's role in regulating apoptosis and cell survival pathways further highlights its significance in maintaining cellular integrity. The generation of recombinant LONRF2 for experimental use has opened new avenues for studying its structural and functional properties, providing insights into its mechanisms of action and potential as a therapeutic target. Understanding LONRF2 is crucial for elucidating its functions in cellular processes and its implications in human diseases, paving the way for potential interventions that could enhance mitochondrial function and combat related pathologies.
