Analytical Data
-
Gene name
HTR1B
- Application
-
Alternative Names
HTR1B；HTR1DB；5-hydroxytryptamine receptor 1B
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P28222
-
Expression Region
1-390aa
-
AA Sequence
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
-
Molecular Weight
45.1 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The HTR1B gene encodes the 5-hydroxytryptamine receptor 1B (5-HT1B), a member of the serotonin receptor family, which plays a crucial role in the modulation of neurotransmission and is involved in various neurological and psychiatric conditions. Research on HTR1B recombinant proteins has gained significant attention due to their potential implications in drug development and therapeutic applications. Dysfunction in serotonin signaling, linked to disorders such as depression, anxiety, and schizophrenia, highlights the importance of understanding the structure and function of 5-HT1B receptors. By producing HTR1B recombinant proteins, researchers aim to investigate their biochemical properties, signaling mechanisms, and interactions with potential pharmacological agents. Experimental studies using these proteins can help elucidate receptor conformations, ligand binding affinities, and downstream signaling pathways, fostering the design of targeted therapies. Furthermore, HTR1B's involvement in the regulation of mood and behavior positions it as a promising target for developing new antidepressants and anxiolytics, thereby addressing the growing need for effective treatments in mental health. Overall, the study of HTR1B recombinant proteins is pivotal for advancing our understanding of serotonin receptors and their roles in health and disease.
