Analytical Data
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基因名
CALCOCO2
- Application
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别名
CALCOCO2；Microtubule-associated Proteins 1A/1B light chain 3C
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13137
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表达区间
1-446aa
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氨基酸序列
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL
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分子量
53.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CALCOCO2, also known as calcium binding and coiled-coil domain 2, is a protein that plays a pivotal role in various cellular processes, particularly in immune response and autophagy. Its unique structure, featuring coiled-coil domains, allows it to interact with several key proteins in signaling pathways, making it an important player in the regulation of cellular function. Research on CALCOCO2 has gained momentum due to its association with human diseases, including autoimmune disorders and cancer. Studies have shown that CALCOCO2 can influence the activation of immune cells and the clearance of damaged organelles, which are critical for maintaining cellular homeostasis. Furthermore, its involvement in the regulation of mitophagy—autophagic degradation of mitochondria—highlights its significance in cellular energy metabolism and stress responses. Given its multifaceted roles, the recombinant expression of CALCOCO2 has become an area of interest, aiming to elucidate its functional mechanisms and interactions at the molecular level. Understanding CALCOCO2's behavior in a controlled, recombinant form can unveil potential therapeutic targets and strategies for treating related diseases. Hence, the study of CALCOCO2 not only enhances our understanding of fundamental biological processes but also paves the way for innovative approaches in medical interventions.
