Analytical Data
-
Gene name
CALCOCO2
- Application
-
Alternative Names
CALCOCO2；Microtubule-associated Proteins 1A/1B light chain 3C
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q13137
-
Expression Region
1-446aa
-
AA Sequence
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL
-
Molecular Weight
53.3 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CALCOCO2, also known as calcium binding and coiled-coil domain 2, is a protein that plays a pivotal role in various cellular processes, particularly in immune response and autophagy. Its unique structure, featuring coiled-coil domains, allows it to interact with several key proteins in signaling pathways, making it an important player in the regulation of cellular function. Research on CALCOCO2 has gained momentum due to its association with human diseases, including autoimmune disorders and cancer. Studies have shown that CALCOCO2 can influence the activation of immune cells and the clearance of damaged organelles, which are critical for maintaining cellular homeostasis. Furthermore, its involvement in the regulation of mitophagy—autophagic degradation of mitochondria—highlights its significance in cellular energy metabolism and stress responses. Given its multifaceted roles, the recombinant expression of CALCOCO2 has become an area of interest, aiming to elucidate its functional mechanisms and interactions at the molecular level. Understanding CALCOCO2's behavior in a controlled, recombinant form can unveil potential therapeutic targets and strategies for treating related diseases. Hence, the study of CALCOCO2 not only enhances our understanding of fundamental biological processes but also paves the way for innovative approaches in medical interventions.
