Analytical Data
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基因名
ZDHHC5
- Application
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别名
ZDHHC5；KIAA1748；ZNF375；Palmitoyltransferase ZDHHC5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9C0B5
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表达区间
60-148aa
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氨基酸序列
ANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRY
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分子量
12.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZDHHC5 (Zinc Finger DHHC-Type Containing 5) is a highly conserved protein that plays a crucial role in the palmitoylation of various substrates, a post-translational modification process that adds palmitic acid, thereby influencing protein localization, stability, and function. Recent studies have highlighted the importance of ZDHHC5 in neuronal development and synaptic function, suggesting its involvement in cognitive processes and neurodegenerative diseases. Its dysregulation has been linked to disorders such as schizophrenia and autism spectrum disorders, emphasizing the need for further research into its mechanisms of action. The expression and activity of ZDHHC5 are regulated by various signaling pathways, making it a potential therapeutic target. Understanding its functional dynamics could provide insights into the molecular basis of related diseases and pave the way for novel treatments. The recombinant production of ZDHHC5 offers a valuable tool for studying its biochemical properties and interactions, facilitating the exploration of its roles in cellular physiology and pathology. As the demand for elucidating the mechanistic underpinnings of palmitoylation increases, ZDHHC5 stands out as a significant focus of research within the broader context of neurobiology and cellular signal transduction.
