Analytical Data
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基因名
gp210
- Application
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别名
gp210；KIAA0906；Nuclear pore membrane glycoProtein 210
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TEM1
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表达区间
28-238aa
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氨基酸序列
LNIPKVLLPFTRATRVNFTLEASEGCYRWLSTRPEVASIEPLGLDEQQCSQKAVVQARLTQPARLTSIIFAEDITTGQVLRCDAIVDLIHDIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFEWTIVKDSEADRFSDSHNALRILTFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLL
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分子量
27.6kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GP210 is a protein that plays a crucial role in the formation and function of hepatic bile canaliculi, and it is encoded by the gene that is essential for normal liver development. Research on GP210 has gained significant attention due to its association with various liver diseases, particularly those related to cholestasis, such as progressive familial intrahepatic cholestasis (PFIC) and primary biliary cholangitis (PBC). Mutations in the GP210 gene can disrupt bile transport, leading to impaired bile flow and subsequent liver damage. Understanding the structure and function of GP210 can provide insights into the molecular mechanisms underlying these diseases and facilitate the development of targeted therapies. Additionally, GP210 has potential as a biomarker for liver diseases, making it relevant for diagnostic purposes. Recent advances in recombinant protein technology have enabled the production of GP210 in laboratory settings, allowing researchers to investigate its characteristics and interactions in detail. This research is pivotal for identifying therapeutic targets and designing novel treatment strategies for liver diseases involving bile duct abnormalities. As a result, GP210 recombinant protein studies are crucial for better understanding liver pathology and improving patient outcomes in liver-related disorders.
