Analytical Data
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基因名
IKBIP
- Application
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别名
IKBIP；IKIP；Inhibitor of nuclear factor kappa-B kinase-interacting Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q70UQ0
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表达区间
1-350aa
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氨基酸序列
MSEVKSRKKSGPKGAPAAEPGKRSEGGKTPVARSSGGGGWADPRTCLSLLSLGTCLGLAWFVFQQSEKFAKVENQYQLLKLETNEFQQLQSKISLISEKWQKSEAIMEQLKSFQIIAHLKRLQEEINEVKTWSNRITEKQDILNNSLTTLSQDITKVDQSTTSMAKDVGLKITSVKTDIRRISGLVTDVISLTDSVQELENKIEKVEKNTVKNIGDLLSSSIDRTATLRKTASENSQRINSVKKTLTELKSDFDKHTDRFLSLEGDRAKVLKTVTFANDLKPKVYNLKKDFSRLEPLVNDLTLRIGRLVTDLLQREKEIAFLSEKISNLTIVQAEIKDIKDEIAHISDMN
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分子量
39.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IKBIP, or Inhibitor of Nuclear Factor kappa-B Kinase Beta Interacting Protein, has garnered significant attention in recent years due to its pivotal role in immune response regulation and inflammation. Research indicates that IKBIP acts as a crucial modulator within the NF-κB signaling pathway, which is vital for various cellular processes, including cell proliferation, survival, and apoptosis. Dysregulation of this pathway is implicated in numerous diseases, including cancers, autoimmune disorders, and chronic inflammatory conditions. Consequently, understanding the structural and functional properties of IKBIP is essential for the development of targeted therapeutic strategies. Recent advancements in recombinant protein technology have facilitated the production and characterization of IKBIP, allowing researchers to dissect its interactions with other signaling molecules and its role in the regulation of NF-κB activity. Studies utilizing recombinant IKBIP have revealed insights into its structural domains, functional mechanisms, and potential as a therapeutic target, highlighting its importance in both basic and translational research. The growing interest in IKBIP underscores the need for further exploration of its biological functions and implications in health and disease.
