Analytical Data
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Gene name
IKBIP
- Application
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Alternative Names
IKBIP；IKIP；Inhibitor of nuclear factor kappa-B kinase-interacting Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q70UQ0
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Expression Region
1-350aa
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AA Sequence
MSEVKSRKKSGPKGAPAAEPGKRSEGGKTPVARSSGGGGWADPRTCLSLLSLGTCLGLAWFVFQQSEKFAKVENQYQLLKLETNEFQQLQSKISLISEKWQKSEAIMEQLKSFQIIAHLKRLQEEINEVKTWSNRITEKQDILNNSLTTLSQDITKVDQSTTSMAKDVGLKITSVKTDIRRISGLVTDVISLTDSVQELENKIEKVEKNTVKNIGDLLSSSIDRTATLRKTASENSQRINSVKKTLTELKSDFDKHTDRFLSLEGDRAKVLKTVTFANDLKPKVYNLKKDFSRLEPLVNDLTLRIGRLVTDLLQREKEIAFLSEKISNLTIVQAEIKDIKDEIAHISDMN
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Molecular Weight
39.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IKBIP, or Inhibitor of Nuclear Factor kappa-B Kinase Beta Interacting Protein, has garnered significant attention in recent years due to its pivotal role in immune response regulation and inflammation. Research indicates that IKBIP acts as a crucial modulator within the NF-κB signaling pathway, which is vital for various cellular processes, including cell proliferation, survival, and apoptosis. Dysregulation of this pathway is implicated in numerous diseases, including cancers, autoimmune disorders, and chronic inflammatory conditions. Consequently, understanding the structural and functional properties of IKBIP is essential for the development of targeted therapeutic strategies. Recent advancements in recombinant protein technology have facilitated the production and characterization of IKBIP, allowing researchers to dissect its interactions with other signaling molecules and its role in the regulation of NF-κB activity. Studies utilizing recombinant IKBIP have revealed insights into its structural domains, functional mechanisms, and potential as a therapeutic target, highlighting its importance in both basic and translational research. The growing interest in IKBIP underscores the need for further exploration of its biological functions and implications in health and disease.
