Analytical Data
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基因名
TTPa
- Application
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别名
TTPa；TPP1；Alpha-tocopherol transfer Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49638
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表达区间
1-278aa
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氨基酸序列
MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEISADLHPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIAHWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFPDILPLEYGGEEFSMEDICQEWTNFIMKSEDYLSSISESIQ
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分子量
39.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TTPa, or TTP (Tristetraprolin), is a member of the zinc-finger protein family and plays a crucial role in the regulation of mRNA stability and decay. This protein is particularly notable for its involvement in the inflammatory response, as it binds to AU-rich elements in the 3' untranslated regions of various pro-inflammatory cytokine mRNAs, promoting their degradation. Research into TTPa has gained momentum due to its potential implications in various diseases, including autoimmune disorders, cancers, and chronic inflammatory conditions. Understanding TTPa’s mechanisms can provide insights into the regulation of gene expression and offer novel therapeutic targets. The recombinant production of TTPa allows for in-depth studies of its structure-function relationship, interactions with other cellular proteins, and its role in post-transcriptional regulation. Moreover, characterizing TTPa in vitro can facilitate the development of small molecules or biologics that could modulate its activity, thereby offering new strategies for treating diseases associated with dysregulated inflammation. Overall, TTPa research contributes to the broader field of molecular biology and therapeutic development.
