Cat: PA1000-2014

Recombinant Human MRPL1 Protein,His

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Analytical Data

  • 基因名

    MRPL1

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    MRPL1;Large ribosomal subunit Protein uL1m

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q9BYD6

  • 表达区间

    51-325aa

  • 氨基酸序列

    MGSSHHHHHH SSGLVPRGSH MGSKKTKKGA KEKTPDEKKD EIEKIKAYPY MEGEPEDDVY LKRLYPRQIY EVEKAVHLLK KFQILDFTSP KQSVYLDLTL DMALGKKKNV EPFTSVLSLP YPFASEINKV AVFTENASEV KIAEENGAAF AGGTSLIQKI WDDEIVADFY VAVPEIMPEL NRLRKKLNKK YPKLSRNSIG RDIPKMLELF KNGHEIKVDE ERENFLQTKI ATLDMSSDQI AANLQAVINE VCRHRPLNLG PFVVRAFLRS STSEGLLLKI DPLLPKEVKN EESEKEDA

  • 分子量

    34 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

MRPL1, or Mitochondrial Ribosomal Protein L1, is a vital component of the mitochondrial ribosome, which plays a critical role in protein synthesis within the mitochondria. Mitochondria are often referred to as the "powerhouses" of the cell, as they are responsible for energy production through oxidative phosphorylation. The functional integrity of MRPL1 is essential for maintaining mitochondrial protein synthesis, which is crucial for the proper functioning of respiratory complexes and overall cellular metabolism. Research has shown that mutations or deficiencies in MRPL1 can lead to a variety of mitochondrial disorders, including those affecting energy production, neurodegeneration, and myopathies. Understanding the structure, function, and interaction of MRPL1 with other mitochondrial components is essential for elucidating the pathophysiological mechanisms underlying these diseases. Moreover, the study of MRPL1 may provide insights into developing targeted therapies aimed at ameliorating mitochondrial dysfunction. Advances in techniques such as cryo-electron microscopy and molecular modeling have opened new avenues for exploring the biogenesis and regulation of mitochondrial ribosomes, making MRPL1 a significant focus in mitochondrial research. As our understanding of MRPL1's role in mitochondrial dynamics continues to grow, it presents opportunities for therapeutic intervention in mitochondrial-related diseases, highlighting its importance in both fundamental biology and clinical applications.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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