Analytical Data
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Gene name
MRPL1
- Application
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Alternative Names
MRPL1;Large ribosomal subunit Protein uL1m
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BYD6
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Expression Region
51-325aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSKKTKKGA KEKTPDEKKD EIEKIKAYPY MEGEPEDDVY LKRLYPRQIY EVEKAVHLLK KFQILDFTSP KQSVYLDLTL DMALGKKKNV EPFTSVLSLP YPFASEINKV AVFTENASEV KIAEENGAAF AGGTSLIQKI WDDEIVADFY VAVPEIMPEL NRLRKKLNKK YPKLSRNSIG RDIPKMLELF KNGHEIKVDE ERENFLQTKI ATLDMSSDQI AANLQAVINE VCRHRPLNLG PFVVRAFLRS STSEGLLLKI DPLLPKEVKN EESEKEDA
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Molecular Weight
34 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL1, or Mitochondrial Ribosomal Protein L1, is a vital component of the mitochondrial ribosome, which plays a critical role in protein synthesis within the mitochondria. Mitochondria are often referred to as the "powerhouses" of the cell, as they are responsible for energy production through oxidative phosphorylation. The functional integrity of MRPL1 is essential for maintaining mitochondrial protein synthesis, which is crucial for the proper functioning of respiratory complexes and overall cellular metabolism. Research has shown that mutations or deficiencies in MRPL1 can lead to a variety of mitochondrial disorders, including those affecting energy production, neurodegeneration, and myopathies. Understanding the structure, function, and interaction of MRPL1 with other mitochondrial components is essential for elucidating the pathophysiological mechanisms underlying these diseases. Moreover, the study of MRPL1 may provide insights into developing targeted therapies aimed at ameliorating mitochondrial dysfunction. Advances in techniques such as cryo-electron microscopy and molecular modeling have opened new avenues for exploring the biogenesis and regulation of mitochondrial ribosomes, making MRPL1 a significant focus in mitochondrial research. As our understanding of MRPL1's role in mitochondrial dynamics continues to grow, it presents opportunities for therapeutic intervention in mitochondrial-related diseases, highlighting its importance in both fundamental biology and clinical applications.
