Analytical Data
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Gene name
TRAF3
- Application
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Alternative Names
TRAF3；CAP-1；CRAF1；TRAFAMN；TNF receptor-associated factor 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13114
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Expression Region
1-568aa
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AA Sequence
MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDK YKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKV FKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVR PDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCV VVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKA HEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSM KSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLA DMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYF GYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMD QGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIK DDTIFIKVIVDTSDLPDP
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Molecular Weight
91 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRAF3 (TNF Receptor-Associated Factor 3) is a pivotal protein involved in various cellular processes, notably in immune responses and inflammation. It functions as an adapter molecule that mediates signaling from several receptors, including those of the tumor necrosis factor (TNF) superfamily and toll-like receptors (TLRs). The significance of TRAF3 is evident in its regulatory role in the activation of multiple downstream signaling pathways, particularly the NF-kB and MAPK pathways, which are crucial for the survival and activation of immune cells. Dysregulation of TRAF3 has been implicated in various diseases, including autoimmune disorders and cancers, highlighting its potential as a therapeutic target. Research into TRAF3 recombinant proteins has gained momentum as scientists seek to elucidate its structural and functional properties. This research is focused on understanding the molecular mechanisms by which TRAF3 exerts its effects in the immune system. Recombinant TRAF3 proteins can be utilized in various assays to study their interactions with other signaling molecules, assess their functional roles in vivo, and evaluate their potential in drug discovery. By gaining insights into TRAF3's dynamics, researchers aim to develop novel therapeutic strategies that can modulate its activity and offer new treatments for immune-related diseases, making it a focal point of investigation in both immunology and biotechnology.
