Analytical Data
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基因名
MRM1
- Application
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别名
MRM1;rRNA methyltransferase 1. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6IN84
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表达区间
21-353aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSSHAARHG ERPGGEELSR LLLDDLVPTS RLELLFGMTP CLLALQAARR SVARLLLQAG KAGLQGKRAE LLRMAEARDI PVLRPRRQKL DTMCRYQVHQ GVCMEVSPLR PRPWREAGEA SPGDDPQQLW LVLDGIQDPR NFGAVLRSAH FLGVDKVITS RRNSCPLTPV VSKSSAGAME VMDVFSTDDL TGFLQTKAQQ GWLVAGTVGC PSTEDPQSSE IPIMSCLEFL WERPTLLVLG NEGSGLSQEV QASCQLLLTI LPRRQLPPGL ESLNVSVAAG ILLHSICSQR KGFPTEGERR QLLQDPQEPS ARSEGLSMAQ HPGLSSGPEK ERQNEG
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分子量
39 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRM1, also known as mitochondrial RNA methyltransferase 1, is an essential enzyme involved in the post-transcriptional modification of mitochondrial tRNAs. Understanding MRM1's function is crucial as it plays a significant role in mitochondrial gene expression, influencing cellular energy metabolism and overall cellular health. Abnormalities in MRM1 activity have been linked to various mitochondrial diseases, neurodegenerative disorders, and aging-related pathologies. The enzyme specifically catalyzes the methylation of certain nucleosides within mitochondrial tRNAs, which is vital for maintaining the stability and proper functioning of these molecules during protein synthesis. Research on MRM1 has gained momentum due to its potential implications in therapeutic strategies against mitochondrial dysfunction. Advancements in structural biology and biochemistry techniques have facilitated the exploration of MRM1's enzymatic mechanisms, substrate specificity, and interaction with other cellular factors. Studying MRM1 not only enhances our understanding of mitochondrial biology but also opens avenues for developing targeted therapies for diseases associated with mitochondrial dysfunction. As such, MRM1 serves as a compelling subject for ongoing research in the fields of molecular biology, genetics, and medicine.
