Analytical Data
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Gene name
LASS6
- Application
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Alternative Names
CERS6; LASS6; Ceramide synthase 6; CerS6; LAG1 longevity assurance homolog 6; Sphingoid base N-palmitoyltransferase CERS6
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6ZMG9
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Expression Region
1-38aa
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AA Sequence
MIEVILSLAQMRRTQNLRERIPTLRQPPMGPVVPTGIS
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Molecular Weight
30.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LASS6 (Lipid Metabolism and Synthesis 6) is a member of the LASS family, which encodes enzymes involved in the synthesis of sphingolipids, a class of lipids crucial for various cellular processes, including membrane structure, signaling, and cell growth. Research into LASS6 has gained momentum due to its potential implications in human health and disease, particularly in relation to metabolic disorders and certain types of cancer. Abnormal sphingolipid metabolism has been linked to various pathologies, and LASS6's role in this pathway positions it as a key player in maintaining lipid homeostasis. Furthermore, recent studies have shown that LASS6 expression levels can vary in different tissues and under various physiological conditions, suggesting its involvement in tissue-specific functions and responses. Understanding the biochemical properties and regulatory mechanisms of LASS6 could provide insights into therapeutic targets for diseases associated with lipid dysregulation. As such, the recombinant production of LASS6 protein is essential for functional studies, allowing researchers to investigate its enzymatic activity, substrate specificity, and interaction with other metabolic pathways. This knowledge could contribute to a better understanding of LASS6's role in disease and its potential as a biomarker or therapeutic target in metabolic and oncological research. Therefore, the study of LASS6 recombinant protein plays a critical role in advancing our understanding of lipid metabolism and its implications in human health.
