Analytical Data
-
基因名
LASS5
- Application
-
别名
CERS5; LASS5; Ceramide synthase 5; CerS5; LAG1 longevity assurance homolog 5; Sphingoid base N-palmitoyltransferase CERS5; Sphingosine N-acyltransferase CERS5
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q8N5B7
-
表达区间
63-147aa
-
氨基酸序列
LFERFIAKPCALRIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWR
-
分子量
35.09 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LASS5, or Longevity Assurance Homolog 5, is a member of the LASS gene family that plays a crucial role in sphingolipid metabolism and cellular signaling. Research on LASS5 has gained prominence due to its involvement in various biological processes, including cell proliferation, differentiation, and apoptosis, which are vital for maintaining cellular homeostasis. Dysregulation of LASS5 has been linked to several diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. The reconstitution of LASS5 as a recombinant protein allows for detailed studies of its functional properties, enzymatic activities, and interactions within cellular pathways. Understanding the structure-function relationship of this protein is essential for uncovering its role in health and disease. Furthermore, recombinant LASS5 can be utilized in drug discovery processes, enabling the identification of small molecules that can modulate its activity. This research could pave the way for innovative therapeutic strategies aimed at targeting sphingolipid metabolism, offering new avenues for the treatment of various pathological conditions. Overall, the study of LASS5 and its associated recombinant protein holds significant promise for advancing our understanding of cellular mechanisms and developing novel therapeutic interventions.












