Analytical Data
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Gene name
Ptger2
- Application
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Alternative Names
Ptger2；PTGER2；Prostaglandin E2 receptor EP4 subtype
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35408
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Expression Region
1-488aa
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AA Sequence
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
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Molecular Weight
53.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The research on Ptger2 recombinant protein has garnered significant attention due to the critical role of the prostaglandin E2 (PGE2) signaling pathway in various physiological and pathological processes. Ptger2, or the prostaglandin E receptor 2, is one of the four receptors for PGE2 and is involved in mediating its diverse effects, which include inflammatory responses, pain modulation, and regulation of immune functions. Dysregulation of the Ptger2 signaling pathway has been implicated in several conditions, such as cancer, cardiovascular diseases, and neurodegenerative disorders. The production of Ptger2 recombinant protein allows for detailed studies on its structure, function, and interactions with ligands. This research provides insights into the receptor's signaling mechanisms and aids in identifying potential therapeutic targets for modulating PGE2-related pathways. Additionally, recombinant Ptger2 protein can be utilized in drug discovery efforts, where small molecules or antibodies can be screened for their efficacy in modulating receptor activity. Understanding the biological role of Ptger2 through recombinant technology is essential for elucidating its contributions to health and disease, paving the way for novel therapeutic strategies.
