Analytical Data
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Gene name
CACNa1E
- Application
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Alternative Names
CACNa1E；EF-hand domain-containing Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15878
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
261 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CACNa1E, a member of the voltage-gated calcium channel family, plays a crucial role in the regulation of calcium ion influx across the plasma membrane, which is essential for various physiological processes, including neurotransmitter release, muscle contraction, and gene expression. Research on CACNa1E has gained significant attention due to its implications in neurological disorders, cardiovascular diseases, and other health issues. The reconstitution and characterization of CACNa1E recombinant protein have become pivotal for understanding its structure-function relationships and pharmacological properties. By studying this protein, researchers aim to elucidate the molecular mechanisms underlying its activity and to identify potential therapeutic targets for diseases associated with calcium channel dysfunction. Advances in molecular biology techniques, such as recombinant DNA technology and expression systems, have facilitated the production of high-purity CACNa1E proteins, allowing for detailed functional assays and structural analyses. These studies are vital not only for enhancing our understanding of calcium channels in health and disease but also for developing innovative strategies for drug discovery aimed at modulating CACNa1E activity.
