Analytical Data
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基因名
CACNa1F
- Application
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别名
CACNa1F；CACNAF1；Voltage-dependent L-type calcium channel subunit alpha-1F
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60840
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表达区间
全长
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氨基酸序列
full
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分子量
220 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CACNA1F encodes a critical subunit of voltage-gated calcium channels, which play essential roles in various physiological processes, including muscle contraction, neurotransmitter release, and the regulation of gene expression. Mutations in the CACNA1F gene have been implicated in several disorders, including congenital stationary night blindness and certain types of epilepsy, highlighting its importance in neuronal function and health. Research into the recombinant protein of CACNA1F focuses on understanding its structure-function relationships and how specific mutations can disrupt its normal activity. The availability of this recombinant protein allows scientists to study its biophysical properties, ion channel dynamics, and interactions with other cellular proteins in a controlled environment. This knowledge is crucial for elucidating the mechanisms underlying disease states associated with CACNA1F and can potentially lead to the development of targeted therapeutic strategies. Additionally, studying the recombinant protein can provide insights into the general principles governing voltage-gated calcium channel function, contributing to the broader fields of neurobiology and pharmacology.
