Analytical Data
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Gene name
CACNa1C
- Application
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Alternative Names
CACNa1C；CACNLB3；Voltage-dependent L-type calcium channel subunit beta-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13936
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
248.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CACNA1C, the gene encoding the L-type voltage-gated calcium channel Cav1.2, plays a crucial role in calcium ion influx, which is essential for various physiological processes, including muscle contraction, neurotransmitter release, and cardiac function. Mutations in CACNA1C have been linked to a range of disorders, such as Timothy syndrome, which entails cardiac arrhythmias, autism spectrum disorders, and other developmental issues. Understanding the structure and function of the CACNA1C protein is vital for elucidating its role in these pathologies and for developing targeted therapies. The production of recombinant CACNA1C protein enables researchers to investigate its biophysical properties, interaction with regulatory proteins, and the effects of specific mutations on channel function. Additionally, studying the protein in vitro using purified or reconstituted channels allows for detailed mechanistic insights into its operation and pharmacological modulation. Overall, research on CACNA1C recombinant protein is pivotal for advancing our knowledge of calcium signaling and its implications in human health and disease.
