Analytical Data
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基因名
L3MBTL4
- Application
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别名
L3MBTL4; Lethal(3)malignant brain tumor-like protein 4; H-l(3)mbt-like protein 4; L(3)mbt-like protein 4; L3mbt-like 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NA19
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表达区间
1-623aa
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氨基酸序列
MKQPNRKRKL NMDSKERLDQ DGRLEQAEEE KKPKDSTTPL SHVPSAAAQG AWSWEWYLKE QKAVAAPVEL FSKDQSFPEH ENGFQIGMRL EGIDPRHPSV FCVLSVAEVC GYRLRLHFDG YLSCYDFWTN AGSPDIHPVG WCEKTKHELH IPKGYRKDKF VWMDYLKACK LQNAPKKLFR NRSPNGPMSK EFQVGMKLEA VDRKNPSLVC VATIADIVED RLLVHFDNWD DSYDYWCDVN SPYVQPVGWC QENGRTLIAP QGYPNPENFS WTEYLEATQT NAVPAKVFKM RLPHGFLPNM KLEVVDKRNP RLIRVATIVD VDDQRVKVHF DGWDHKYDYW VEADSPDIHP IGWCDVTGHP LEVPQRTNDL KILPGQAVCP TPGCRGIGHI RGPRYSGHHS AFGCPYSDMN LKKEATLHDR LREQTQANLE SDSSHSKSKS LCSLNFNGKH EKVNSQPRLV QQAKCLKIKG KEDIDLDNLF RVLVLHPRGL EYSVEQAQQV LHQSVSMSTV SAHPFRDLPL GREQHCKLLP GVADIRASQV ARWTVDEVAE FVQSLLGCEE HAKCFKKEQI DGKAFLLLTQ TDIVKVMKIK LGPALKIYNS ILMFRHSQEL PEEDIASGQE VRG
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分子量
71.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
L3MBTL4 (Lethal(3)malignant brain tumor-like 4) is a protein implicated in various cellular processes, including regulation of gene expression and chromatin remodeling. Emerging research highlights its potential role in cancer biology, particularly in the context of tumorigenesis and metastasis. Studies have shown that L3MBTL4 may function as a tumor suppressor, with altered expression levels correlating with malignancies, including breast and colorectal cancers. Furthermore, the protein is involved in key signaling pathways, which positions it as a crucial player in cell cycle regulation and differentiation. Understanding the structural and functional mechanics of L3MBTL4, particularly through the investigation of its recombinant forms, could shed light on its interactions with other cellular components and contribute to the development of novel therapeutic strategies. Recent advancements in protein engineering and expression techniques have made it feasible to produce recombinant L3MBTL4, enabling detailed functional assays and structural analyses. The exploration of this protein's role in health and disease could lead to significant breakthroughs in targeted cancer therapies and personalized medicine.
