Analytical Data
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Gene name
TUBa4A
- Application
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Alternative Names
TUBa4A；TUBA1；Tubulin alpha-4A chain
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P68366
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Expression Region
1-448aa
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AA Sequence
MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGK HVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLD RIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPP TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGIDSYEDEDEGEE
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Molecular Weight
49.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The TUBa4A protein, part of the tubulin alpha chain family, plays a crucial role in the formation and stability of microtubules, which are essential components of the cytoskeleton in eukaryotic cells. Mutations in the TUBA4A gene have been linked to neurodegenerative disorders, particularly a rare form of motor neuron disease known as juvenile amyotrophic lateral sclerosis (jALS). Research into TUBa4A recombinant proteins has gained momentum as scientists aim to understand the structural and functional implications of these mutations on microtubule dynamics and cellular physiology. By producing and characterizing TUBa4A recombinant proteins, researchers can investigate the biochemical properties, interactions, and pathways affected by TUBa4A dysfunction. Furthermore, these studies potentially provide insights into therapeutic strategies for diseases associated with TUBA4A mutations, as understanding the underlying mechanisms may open avenues for targeted interventions. The exploration of TUBa4A protein's role at a molecular level is essential for unraveling the complex mechanisms of neurodegeneration, ultimately contributing to the development of effective treatments for affected individuals.
