Analytical Data
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基因名
TUBa4A
- Application
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别名
TUBa4A；TUBA1；Tubulin alpha-4A chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P68366
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表达区间
1-448aa
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氨基酸序列
MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGK HVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLD RIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPP TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGIDSYEDEDEGEE
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分子量
49.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The TUBa4A protein, part of the tubulin alpha chain family, plays a crucial role in the formation and stability of microtubules, which are essential components of the cytoskeleton in eukaryotic cells. Mutations in the TUBA4A gene have been linked to neurodegenerative disorders, particularly a rare form of motor neuron disease known as juvenile amyotrophic lateral sclerosis (jALS). Research into TUBa4A recombinant proteins has gained momentum as scientists aim to understand the structural and functional implications of these mutations on microtubule dynamics and cellular physiology. By producing and characterizing TUBa4A recombinant proteins, researchers can investigate the biochemical properties, interactions, and pathways affected by TUBa4A dysfunction. Furthermore, these studies potentially provide insights into therapeutic strategies for diseases associated with TUBA4A mutations, as understanding the underlying mechanisms may open avenues for targeted interventions. The exploration of TUBa4A protein's role at a molecular level is essential for unraveling the complex mechanisms of neurodegeneration, ultimately contributing to the development of effective treatments for affected individuals.
