Analytical Data
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Gene name
KRTHA3B
- Application
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Alternative Names
HA 3II; HA3II; Hair keratin; Hair keratin type I Ha3 II; Hard keratin type I 3II; hHa3 II; hHa3II; HKA3B; K33B; Keratin 33B; Keratin; Keratin hair acidic 3B; Keratin hair acidic3B; Keratin type I cuticular Ha3 II; Keratin-33B; Keratin33B; KRT 33B; KRT33B; KRTHA 3B
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14525
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Expression Region
1-404aa
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AA Sequence
MPYNFCLPSLSCRTSCSSRPCVPPSCHGYTLPGACNIPANVSNCNWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQKILCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDELTLCRSDLEAQMESLKEELLSLKQNHEQEVNTLRCQLGDRLNVEVDAAPAVDLNQVLNETRNQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLRYSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCKLPSNPCATTNACEKPIGSCVTNPCGPRSRCGPCNTFGY
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Molecular Weight
70.18 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRTHA3B, a member of the keratin family, is primarily expressed in epithelial tissues and plays a crucial role in maintaining cellular structure and integrity. Its research background stems from the understanding of keratin's significance in various biological processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of keratin expression has been implicated in various pathological conditions, including skin disorders and epithelial cancers. Recent studies have highlighted KRTHA3B's involvement in the structural organization of keratin networks, suggesting its potential role in response to mechanical stress and injury. Additionally, KRTHA3B has been linked to wound healing processes, where its expression appears to be upregulated in healing tissues. Exploring the molecular mechanisms regulating KRTHA3B expression and function may unveil new therapeutic targets for skin-related diseases and improve our understanding of epithelial biology. Consequently, the investigation of KRTHA3B restructuring in vitro and in vivo models is essential to elucidate its functional relevance and potential applications in regenerative medicine and cancer research.
