Analytical Data
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Gene name
MLF1IP
- Application
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Alternative Names
CENPU;ICEN24;KLIP1;MLF1IP;Centromere Protein U
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q71F23
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Expression Region
147-418aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSTRRKVKS AEKISTQRHE VIRTTASSEL SEKPAESVTS KKTGPLSAQP SVEKENLAIE SQSKTQKKGK ISHDKRKKSR SKAIGSDTSD IVHIWCPEGM KTSDIKELNI VLPEFEKTHL EHQQRIESKV CKAAIATFYV NVKEQFIKML KESQMLTNLK RKNAKMISDI EKKRQRMIEV QDELLRLEPQ LKQLQTKYDE LKERKSSLRN AAYFLSNLKQ LYQDYSDVQA QEPNVKETYD SSSLPALLFK ARTLLGAESH LRNINHQLEK LLDQG
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Molecular Weight
34 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MLF1IP, or MLF1-interacting protein, has emerged as a significant focus of research due to its critical role in cellular processes and potential implications in various diseases. It was initially identified through its interaction with the MLF1 protein, which is known for its involvement in hematopoiesis and cell differentiation. The MLF1IP protein is believed to participate in the regulation of gene expression and potentially in the modulation of cellular stress responses. Research has indicated that MLF1IP may have implications in the development of hematological malignancies, as altered expression levels have been observed in certain cancer types. Furthermore, its interaction with other proteins suggests that MLF1IP might play a pivotal role in signaling pathways that govern cell survival and proliferation. As a result, understanding the structure and function of MLF1IP through the development of recombinant protein variants could pave the way for novel therapeutic strategies. The study of MLF1IP not only enhances our comprehension of fundamental biological processes but also opens new avenues for targeted interventions in cancer and other diseases linked to hematopoietic dysfunction. The investigation into MLF1IP's mechanisms at the molecular level continues to be a fruitful area for both basic and translational research, aiming to uncover its full potential in medical science.
