Analytical Data
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Gene name
UBA52
- Application
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Alternative Names
UBA52；UBCEP2；Ubiquitin-ribosomal Protein eL40 fusion Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P62987
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Expression Region
29-128aa
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AA Sequence
KIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGII EPSLRQLAQKYNCDKMICRKCYARLHPRAVNCRKKKCGHTNNLRPKKKVK
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Molecular Weight
14.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBA52 is a pivotal protein that plays a crucial role in the ubiquitin-proteasome system, which is essential for regulating protein degradation and maintaining cellular homeostasis. This protein consists of a fusion of ubiquitin and ribosomal protein L52, and its dual functionality is significant in various cellular processes such as signal transduction, inflammation, and stress responses. The study of UBA52 has gained attention due to its involvement in pathophysiological conditions, including cancer and neurodegenerative diseases, where dysregulation of protein degradation pathways is often observed. Research has highlighted that UBA52 not only contributes to the ubiquitination process but also influences ribosome biogenesis and protein synthesis. Understanding the structural and functional aspects of UBA52 can provide insights into its biological mechanisms and potential therapeutic targets. Furthermore, investigating UBA52's interactions with other proteins and its regulation under different physiological states could lead to new avenues for drug development, particularly in diseases characterized by proteostasis imbalance. As a result, UBA52 has emerged as a significant focus in molecular biology and biomedical research, with implications for developing innovative treatments for various diseases linked to the ubiquitin-proteasome pathway.
