Analytical Data
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基因名
MIA
- Application
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别名
MIA;Melanoma-derived growth regulatory Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16674
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表达区间
25-131aa
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氨基酸序列
GPMPKLADRK LCADQECSHP ISMAVALQDY MAPDCRFLTI HRGQVVYVFS KLKGRGRLFW GGSVQGDYYG DLAARLGYFP SSIVREDQTL KPGKVDVKTD KWDFYCQ
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分子量
12.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MIA (Melanoma Inhibitory Activity) is a protein originally identified in the context of melanoma, a type of skin cancer, known for its role in tumor progression and metastasis. Research into MIA has revealed its potential significance not only as a biomarker for melanoma diagnosis but also as a therapeutic target due to its involvement in cell survival and proliferation pathways. MIA protein is secreted by melanoma cells, and its elevated levels in the serum of patients have been correlated with poor prognosis and advanced disease stages. Moreover, MIA has been shown to interact with various cellular processes, including the regulation of extracellular matrix components and immune evasion mechanisms. As a result, the study of MIA recombinant proteins has gained momentum in recent years, aiming to elucidate its structural and functional properties, as well as its potential applications in diagnostics and targeted therapies. Researchers are exploring the use of recombinant MIA in developing novel therapeutic strategies, including antibody-based approaches and targeted delivery systems, to improve treatment outcomes for melanoma patients. This growing interest underscores the importance of understanding MIA at a molecular level to harness its diagnostic and therapeutic potential effectively.
