Analytical Data
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基因名
MAP3K12
- Application
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别名
MBIP;MAP3K12-binding inhibitory Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NS73
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表达区间
1-344aa
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氨基酸序列
MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP
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分子量
94 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP3K12, also known as Mitogen-Activated Protein Kinase Kinase Kinase 12, is a serine/threonine kinase that plays a crucial role in the MAPK signaling pathway, which is involved in various cellular processes including proliferation, differentiation, and apoptosis. Its importance in cellular communication and response to extracellular signals has drawn significant research interest, particularly in the context of cancer biology, where abnormal activation of MAPK pathways is often implicated. The study of MAP3K12's structure and function can provide insights into its specific roles in these processes. Recombining MAP3K12 allows researchers to produce the protein in a controlled environment, facilitating detailed investigations into its biochemical properties, interactions with other signaling molecules, and contributions to disease mechanisms. Additionally, analyzing MAP3K12 may reveal potential therapeutic targets or biomarkers for diseases associated with dysregulated MAPK signaling. Thus, understanding MAP3K12 at the molecular level is essential for advancing our knowledge of intricate cellular networks and developing effective treatments for related pathologies.
