Analytical Data
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Gene name
JNK1
- Application
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Alternative Names
JNK1；JNK1；PRKM8；SAPK1；Mitogen-activated Protein kinase 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P45983
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Expression Region
4-422aa
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AA Sequence
SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGP
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Molecular Weight
51.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
JNK1, or c-Jun N-terminal kinase 1, is a critical member of the mitogen-activated protein kinase (MAPK) family, playing a pivotal role in various cellular processes, including apoptosis, proliferation, and stress response. Its activation is associated with a variety of physiological and pathological conditions, including neurodegenerative diseases, cancer, and metabolic disorders. Given its involvement in these processes, JNK1 has emerged as a potential therapeutic target. Recent studies have focused on the recombinant production of JNK1 protein to facilitate detailed functional analyses and structural studies. The ability to produce JNK1 in a recombinant form allows researchers to investigate its biochemical properties, regulatory mechanisms, and interactions with other cellular proteins. Furthermore, understanding JNK1's signaling pathways can aid in the development of novel interventions aimed at modulating its activity for therapeutic benefit. Advances in recombinant DNA technology have significantly streamlined the process, enabling the efficient expression and purification of JNK1, which can be utilized in high-throughput screening assays to identify small molecule modulators. The ongoing research around JNK1 not only enhances our understanding of its biological functions but also paves the way for the potential development of targeted therapies that could significantly impact the treatment of diseases where JNK1 signaling is dysregulated.
