Analytical Data
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Gene name
LRP2BP
- Application
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Alternative Names
LRP2BP;KIAA1325;LRP2-binding Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P2M1
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Expression Region
1-347aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMKLTSEKLPKNPFYASVSQYAAKNQKF FQWKKEKTDYTHANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEE ALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKILDSPCPK ARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKASVKAQS MLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDT EAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVHD IPMIAQVTDCLPEFIGRGMAMASFYHARCLQLGLGITRDETTAKHYYSKA CRLNPALADELHSLLIRQRI
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Molecular Weight
42 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRP2BP (LRP2 binding protein) has emerged as a significant focus in molecular biology due to its role in intercellular signaling and its potential implications in various diseases, particularly cancer. Initially identified as a binding partner for the low-density lipoprotein receptor-related protein 2 (LRP2), LRP2BP is believed to modulate the signaling pathways that govern cell growth, differentiation, and migration. Its interaction with LRP2 suggests a crucial role in the regulation of endocytosis and cellular communication. Moreover, studies have indicated that alterations in LRP2BP expression may be associated with tumor progression and metastasis, making it a candidate for therapeutic targeting. Recent advancements in recombinant protein technology have facilitated the production of LRP2BP in sufficient quantities for structural and functional analysis, allowing researchers to decipher its molecular mechanisms. Understanding how LRP2BP influences cellular processes can provide insights into its potential as a biomarker for disease progression and a target for novel therapeutic strategies. As research continues to unravel the complexities of LRP2BP's role in health and disease, it holds promise for contributing to the development of targeted treatments and improving patient outcomes in conditions where LRP2BP is implicated.
