Analytical Data
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Gene name
KIF11
- Application
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Alternative Names
EG5; HKSP; KIF11; KIF11_HUMAN; Kinesin family member 11; Kinesin like protein 1; Kinesin-like protein 1; Kinesin-like protein KIF11; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; KNSL1; MCLMR; Thyroid receptor-interacting protein 5
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P52732
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Expression Region
947-1056aa
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AA Sequence
LLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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Molecular Weight
37.84 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KIF11, also known as kinesin family member 11, is a molecular motor protein that plays a crucial role in intracellular transport and mitotic spindle dynamics during cell division. As a member of the kinesin superfamily, KIF11 is involved in the transport of various cellular cargoes, including organelles and protein complexes, along microtubules. Its significance has drawn attention in cancer research, as aberrant expression or mutations in KIF11 can lead to dysregulated cellular processes and contribute to tumorigenesis. The study of KIF11 recombinant proteins has become increasingly relevant for understanding its functional mechanisms and potential as a therapeutic target. By producing and analyzing recombinant KIF11 proteins, researchers aim to elucidate the specific roles of this motor protein in cellular logistics and its interaction with microtubules. Such studies may provide insights into the molecular pathways underlying cancer progression and offer avenues for the development of novel anticancer strategies, highlighting KIF11 as a promising candidate for targeted therapies.
