Analytical Data
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基因名
JSRP1
- Application
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别名
JSRP1;JP45;Junctional sarcoplasmic reticulum Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96MG2
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表达区间
1-331aa
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氨基酸序列
MSMTTRAWEE LDGGLGSCQA LEDHSALAET QEDRASATPR LADSGSVPHD SQVAEGPSVD TRPKKMEKEP AARGTPGTGK ERLKAGASPR SVPARKKAQT APPLQPPPPP PALSEELPWG DLSLNKCLVL ASLVALLGSA FQLCRDAVPG EAALQARVPE PWVPPSSAPR EPSSPLPKFE AQAPPSAPPA PRAEAEVRPK IPGSREAAEN DEEEPGEATG EAVREDRVTL ADRGPKERPR REGKPRKEKP RKEERPKKER PRKEERPRAA REPREALPQR WESREGGHRP WARDSRDAEP RKKQAWVSPR RPDEEQRPGS RQKLRAGKGR D
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
JSRP1, or Junctional Sarcoplasmic Reticulum Protein 1, is a member of the junctophilin family, which plays a crucial role in the organization and function of the junctional sarcoplasmic reticulum and plasma membrane in muscle cells. Research on JSRP1 has gained traction due to its potential implications in muscle contraction dynamics and calcium signaling pathways essential for proper muscle function. It has been implicated in various muscular disorders, making it a significant target for understanding disease mechanisms. The protein's structural characteristics and interaction with other muscle proteins are vital for maintaining the integrity of excitation-contraction coupling. Studies have shown that alterations in JSRP1 expression or function can contribute to pathologies such as cardiomyopathies and skeletal muscle diseases. Consequently, recombinant JSRP1 proteins have been developed to elucidate the molecular mechanisms underlying its function and to explore its potential as a therapeutic target. The investigation into JSRP1 not only broadens our understanding of muscle physiology but also opens avenues for innovative treatment strategies for muscle-related diseases. Researchers aim to dissect the functional attributes of JSRP1 through biochemical assays, structural studies, and genetic manipulation in model organisms, ultimately contributing to the development of targeted interventions for muscle disorders.
