Analytical Data
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Gene name
JSRP1
- Application
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Alternative Names
JSRP1;JP45;Junctional sarcoplasmic reticulum Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96MG2
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Expression Region
1-331aa
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AA Sequence
MSMTTRAWEE LDGGLGSCQA LEDHSALAET QEDRASATPR LADSGSVPHD SQVAEGPSVD TRPKKMEKEP AARGTPGTGK ERLKAGASPR SVPARKKAQT APPLQPPPPP PALSEELPWG DLSLNKCLVL ASLVALLGSA FQLCRDAVPG EAALQARVPE PWVPPSSAPR EPSSPLPKFE AQAPPSAPPA PRAEAEVRPK IPGSREAAEN DEEEPGEATG EAVREDRVTL ADRGPKERPR REGKPRKEKP RKEERPKKER PRKEERPRAA REPREALPQR WESREGGHRP WARDSRDAEP RKKQAWVSPR RPDEEQRPGS RQKLRAGKGR D
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
JSRP1, or Junctional Sarcoplasmic Reticulum Protein 1, is a member of the junctophilin family, which plays a crucial role in the organization and function of the junctional sarcoplasmic reticulum and plasma membrane in muscle cells. Research on JSRP1 has gained traction due to its potential implications in muscle contraction dynamics and calcium signaling pathways essential for proper muscle function. It has been implicated in various muscular disorders, making it a significant target for understanding disease mechanisms. The protein's structural characteristics and interaction with other muscle proteins are vital for maintaining the integrity of excitation-contraction coupling. Studies have shown that alterations in JSRP1 expression or function can contribute to pathologies such as cardiomyopathies and skeletal muscle diseases. Consequently, recombinant JSRP1 proteins have been developed to elucidate the molecular mechanisms underlying its function and to explore its potential as a therapeutic target. The investigation into JSRP1 not only broadens our understanding of muscle physiology but also opens avenues for innovative treatment strategies for muscle-related diseases. Researchers aim to dissect the functional attributes of JSRP1 through biochemical assays, structural studies, and genetic manipulation in model organisms, ultimately contributing to the development of targeted interventions for muscle disorders.
