Cat: PA1000-1702

Recombinant Human JMJD7 Protein,His

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Analytical Data

  • Gene name

    JMJD7

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    JMJD7;Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    P0C870

  • Expression Region

    1-316aa

  • AA Sequence

    MGSSHHHHHH SSGLVPRGSH MGSMAEAALE AVRSELREFP AAARELCVPL AVPYLDKPPT PLHFYRDWVC PNRPCIIRNA LQHWPALQKW SLPYFRATVG STEVSVAVTP DGYADAVRGD RFMMPAERRL PLSFVLDVLE GRAQHPGVLY VQKQCSNLPS ELPQLLPDLE SHVPWASEAL GKMPDAVNFW LGEAAAVTSL HKDHYENLYC VVSGEKHFLF HPPSDRPFIP YELYTPATYQ LTEEGTFKVV DEEAMEKVPW IPLDPLAPDL ARYPSYSQAQ ALRCTVRAGE MLYLPALWFH HVQQSQGCIA VNFWYDMEYD LKYSYFQLLD SLTKASGLD

  • Molecular Weight

    38 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

JMJD7 (Jumonji C domain-containing protein 7) is a member of the Jumonji domain-containing (JMJD) protein family, which plays crucial roles in histone modification and epigenetic regulation. Initially identified for its involvement in developmental processes and cellular differentiation, JMJD7 has garnered attention due to its potential implications in various diseases, including cancer. As a histone demethylase, JMJD7 specifically regulates the trimethylation of lysine 9 on histone H3, which is associated with gene silencing and transcriptional repression. Recent studies suggest that aberrant expression of JMJD7 may contribute to the progression of tumors by modulating the expression of key oncogenes and tumor suppressor genes. Additionally, JMJD7 has been implicated in influencing cellular responses to stress and regulating innate immune responses. Consequently, understanding the structure and function of recombinant JMJD7 protein is essential for elucidating its biological roles and therapeutic potential. Research involving the production and characterization of recombinant JMJD7 provides insights into its enzymatic activity, interaction with other proteins, and its role in epigenetic modifications. This growing body of knowledge may ultimately inform the development of novel strategies for targeting JMJD7 in disease contexts, particularly in the realm of cancer therapeutics and precision medicine.

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