Analytical Data
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基因名
JOSD1
- Application
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别名
TAF1D;JOSD3;TATA box-binding Protein-associated factor RNA polymerase I subunit D
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15040
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表达区间
1-202aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMVTPHKKSMLGNGNYDVNVIMAALQTK GYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVR EVGGAYYNLDSKLMSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCA LHALNNVFQDSNAFTRDTLQEIFQRLSPNTKMPEWIGGESELRKFLKHHL RGKNCELLLVVPEEVEAHQSWRTDV
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
JOSD1 (Jumonji/ARID Domain-Containing Protein 1) is a member of the Jumonji domain-containing protein family, which plays a crucial role in various biological processes, including epigenetic regulation, cell differentiation, and development. Recent studies have highlighted its involvement in modulating histone methylation, thereby affecting gene expression and cellular responses. Abnormal expression or mutations in JOSD1 have been linked to several diseases, particularly cancers, suggesting that it may serve as a potential biomarker for diagnosis and a target for therapeutic interventions. The recombinant protein of JOSD1 is being researched to better understand its structure-function relationship and interactions within cellular contexts. Producing JOSD1 as a recombinant protein allows for the exploration of its biochemical properties, stability, and functional mechanisms. This research could also facilitate high-throughput screening for small molecules that can modulate JOSD1 activity, paving the way for novel treatment strategies. Overall, JOSD1's role in epigenetic regulation makes it a significant focus of scientific inquiry, meriting further exploration through the development of recombinant proteins for functional studies and potential clinical applications.
