Analytical Data
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基因名
KDELR2
- Application
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别名
KDELR2; ERD2.2; ER lumen protein-retaining receptor 2; ERD2-like protein 1; ELP-1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P33947
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表达区间
1-212aa
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氨基酸序列
MNIFRLTGDLSHLAAIVILLLKIWKTRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYNTSMKVIYLACSYATVYLIYLKFKATYDGNHDTFRVEFLVVPVGGLSFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLVNWIWRFYFEGFFDLIAVVAGVVQTILYCDFFYLYITKVLKGKKLSLPA
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分子量
50.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KDELR2, or KDEL receptor 2, is a crucial component of the cellular quality control system, primarily involved in the retrieval of misfolded proteins from the endoplasmic reticulum (ER) back to the ER for proper folding. This receptor plays a vital role in maintaining cellular homeostasis and protein stability, making it a key subject of study in the field of molecular biology and biochemistry. Understanding its function and mechanism is particularly important in the context of various diseases, including neurodegenerative disorders and certain cancers, where protein misfolding and accumulation are prominent features. Research on KDELR2 has expanded to explore its structural properties, ligand interactions, and signaling pathways, which are essential for its function. Insights gained from such studies could lead to novel therapeutic approaches targeting protein misfolding diseases by enhancing ER quality control mechanisms or by developing small molecules that modulate KDELR2 activity. Thus, the investigation of KDELR2 recombinant proteins not only enriches our understanding of intracellular transport systems but also holds potential for significant biomedical applications.
