Analytical Data
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基因名
KDELR1
- Application
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别名
KDELR1; ERD2.1; ER lumen protein-retaining receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; Putative MAPK-activating protein PM23
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P24390
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表达区间
1-212aa
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氨基酸序列
MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLDLFTNYISLYNTCMKVVYIACSFTTVWLIYSKFKATYDGNHDTFRVEFLVVPTAILAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGVYRTLYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSLPA
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分子量
50.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KDELR1, or KDEL Receptor 1, is a crucial protein involved in the retention of soluble proteins within the endoplasmic reticulum (ER). Its primary function is to recognize and bind to proteins that carry the KDEL sequence, a retrieval motif that signals for their return to the ER from the Golgi apparatus. Understanding the role of KDELR1 is essential in cellular biology, as it plays a significant part in maintaining protein homeostasis and the proper functioning of the secretory pathway. Dysregulation of KDELR1 has been implicated in various diseases, including neurodegenerative disorders and certain cancers, where improper protein retention and trafficking can lead to cellular stress and dysfunction. Recent studies have focused on the structural and functional characterization of KDELR1, exploring its interactions with KDEL-proteins and other cellular components. This research not only sheds light on KDELR1’s specific mechanisms but also holds promise for therapeutic targets in diseases associated with ER stress and protein misfolding. Advancing the understanding of KDELR1 can potentially lead to innovative strategies for enhancing cellular protein quality control and improving outcomes in related pathological conditions.
