Analytical Data
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基因名
KCTD8
- Application
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别名
KCTD8; BTB/POZ domain-containing protein KCTD8
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6ZWB6
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表达区间
1-473aa
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氨基酸序列
MALKDTGSGGSTILPISEMVSSSSSPGASAAAAPGPCAPSPFPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGARRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFPEKERLLREAEYFQLTDLVKLLSPKVTKQNSLNDEGCQSDLEDNVSQGSSDALLLRGAAAAVPSGPGAHGGGGGGGAQDKRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFDRLSEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFRPPQKIVSPKQEHEDRKHDKVTDKGSESGTSCNELSTSSCDSHSEASTPQDNPSSAQQATAHQPNTLTLDRPSKKAPVQWIPPPDKRRNSELFQTLISKSRETNLSKKKVCEKLSVEEEMKKCIQDFKKIHIPDYFPERKRQWQSELLQKYGL
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分子量
52.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCTD8 (Potassium Channel Tetramerization Domain Containing 8) is a member of the KCTD protein family, which plays significant roles in various cellular processes, including signal transduction, ion channel regulation, and neuronal activity. Recent studies have highlighted KCTD8's involvement in critical biological functions, such as the modulation of potassium channels and the regulation of neurotransmitter release, which could have implications in the context of neurological disorders. The expression of KCTD8 has been linked to diseases like autism spectrum disorders and schizophrenia, making it a potential biomarker or therapeutic target. Understanding the structure and function of KCTD8 through recombinant protein studies is crucial for elucidating its mechanisms of action in neural pathways. By producing and characterizing KCTD8 recombinant proteins, researchers aim to investigate its interactions with other proteins, its effects on cell signaling, and its role in potassium channel activity. This research could provide insights into the molecular basis underlying various psychiatric conditions and pave the way for targeted therapies. Furthermore, KCTD8's unique structural features may facilitate the development of novel pharmacological agents aiming to modulate its activity in disease contexts, thus emphasizing the need for comprehensive studies in this area.
