Analytical Data
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基因名
ITPA
- Application
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别名
ITPA;C20orf37;Inosine triphosphate pyrophosphatase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BY32
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表达区间
3-180aa
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氨基酸序列
ASLVGKKI VFVTGNAKKL EEVVQILGDK FPCTLVAQKI DLPEYQGEPD EISIQKCQEA VRQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL HQLLAGFEDK SAYALCTFAL STGDPSQPVR LFRGRTSGRI VAPRGCQDFG WDPCFQPDGY EQTYAEMPKA EKNAVSHRFR
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of ITPA (Inosine Triphosphate Pyrophosphatase) and its role in protein folding and restructuring has gained significant attention in recent years due to its implications in various biological processes and diseases. ITPA is an essential enzyme that catalyzes the hydrolysis of inosine triphosphate (ITP) to inosine monophosphate (IMP) and inorganic pyrophosphate. This enzymatic activity is crucial in maintaining nucleotide pools and preventing the accumulation of ITP, which can be detrimental to cellular function. Dysregulation of ITPA has been linked to several pathological conditions, including inflammatory diseases and certain types of cancer. Moreover, ITPA's involvement in the cellular stress response underscores its importance in protein homeostasis and the prevention of misfolding or aggregation of proteins. Researchers are increasingly focusing on the mechanistic insights of ITPA in cellular metabolism and its potential as a therapeutic target. Understanding the structure-function relationship of ITPA can provide valuable information for developing novel strategies to manage diseases associated with nucleotide metabolism. Consequently, exploring the restructured forms of ITPA may reveal how it can be modulated in various physiological and pathological contexts, making it a vital area for further investigation.
