Analytical Data
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Gene name
KCTD7
- Application
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Alternative Names
KCTD7; BTB/POZ domain-containing protein KCTD7
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96MP8
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Expression Region
1-289aa
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AA Sequence
MVVVTGREPDSRRQDGAMSSSDAEDDFLEPATPTATQAGHALPLLPQEFPEVVPLNIGGAHFTTRLSTLRCYEDTMLAAMFSGRHYIPTDSEGRYFIDRDGTHFGDVLNFLRSGDLPPRERVRAVYKEAQYYAIGPLLEQLENMQPLKGEKVRQAFLGLMPYYKDHLERIVEIARLRAVQRKARFAKLKVCVFKEEMPITPYECPLLNSLRFERSESDGQLFEHHCEVDVSFGPWEAVADVYDLLHCLVTDLSAQGLTVDHQCIGVCDKHLVNHYYCKRPIYEFKITWW
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Molecular Weight
59.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCTD7, a member of the potassium channel tetramerization domain containing (KCTD) family, is a protein that has garnered significant interest due to its implications in various biological processes and potential links to neurodegenerative disorders. The study of KCTD7 has revealed its essential role in protein-protein interactions, particularly in the modulation of neuronal signaling pathways and involvement in the regulation of synaptic function. Research indicates that mutations in the KCTD7 gene can lead to severe neurological deficits, suggesting its critical role in maintaining normal brain function. Moreover, KCTD7 may participate in the ubiquitin-proteasome system, influencing the degradation of specific substrates and thus affecting cellular homeostasis. The recombinant expression of KCTD7 allows researchers to investigate its structural properties and functional mechanisms, paving the way for potential therapeutic targets in the context of KCTD7-related pathologies. Understanding KCTD7 at the molecular level can provide insights into its role in health and disease, highlighting the importance of its study in the fields of neurobiology and genetics.
