Analytical Data
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Gene name
ITGB3BP
- Application
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Alternative Names
ITGB3BP;CENPR;NRIF3;Centromere Protein R
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13352-5
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Expression Region
1-216aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPFAPVA QARVQWHDFR SLQHLLPAFK RFSCLSLGSS WDYSVKRSLK LDGLLEENSF DPSKITRKKS VITYSPTTGT CQMSLFASPT SSEEQKHRNG LSNEKRKKLN HPSLTESKES TTKDNDEFMM LLSKVEKLSE EIMEIMQNLS SIQALEGSRE LENLIGISCA SHFLKREMQK TKELMTKVNK QKLFEKSTGL PHKASRHLDS YEFLKAILN
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Research on the ITGB3BP (Integrin Beta 3 Binding Protein) recombinant protein has gained prominence due to its critical role in various cellular processes related to integrin signaling. ITGB3BP is known to interact with integrin beta-3, a component of cell adhesion receptors that regulates cell migration, proliferation, and survival. Studies indicate that ITGB3BP is involved in cellular pathways associated with cancer, cardiovascular diseases, and inflammatory responses, making it a significant focus in molecular biology and biomedicine. The ability to produce recombinant ITGB3BP offers insights into its structure-function relationships and potential therapeutic applications. For instance, understanding how this protein modulates integrin activity could pave the way for the development of targeted therapies in cancer treatment by disrupting aberrant cell signaling pathways. Moreover, recombinant forms of ITGB3BP can be utilized in protein-protein interaction studies, providing a platform to explore its interactions with other signaling molecules. This research not only enhances our understanding of fundamental cellular mechanisms but also has implications for innovative treatment strategies in diseases where integrin signaling is disrupted. Overall, the study of ITGB3BP recombinant protein represents a vital intersection of cell biology and therapeutic development, unlocking potential new avenues for medical research and intervention.
