Analytical Data
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基因名
KCTD18
- Application
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别名
KCTD18; BTB/POZ domain-containing protein KCTD18
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6PI47
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表达区间
1-426aa
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氨基酸序列
MEGHKAEEEVLDVLRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRDGRLFKYLLDYLHGEVQIPTDEQTRIALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYATKTDGTDAIEKQLGGRIHSKGIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLLGSLRHMAPIRKRRLITFNEADESVNYKTGPKPVRFLGPSTSTQIKVKNSASVTVSPASAIQTSAGATANRFQSGSRRKAAQRSAPSRATALVGTGAPGHPQASPGAASAENGGTHLPPAKVLLSDKKPTPQRVIKLKRTPLCATAPCLPSPTATRQANSLKPLPGEAARALGVRTENGKNKGN
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分子量
73.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCTD18, a member of the potassium channel tetramerization domain-containing (KCTD) family, has garnered interest in the field of molecular biology due to its potential roles in various physiological and pathological processes. Initially identified as a protein interacting with specific ion channels, recent studies have proposed that KCTD18 is involved in the regulation of cellular signaling pathways, contributing to cellular homeostasis and function. The protein is linked to mechanisms such as cell proliferation, differentiation, and apoptosis, which are crucial in development and disease progression. Furthermore, aberrant expression of KCTD18 has been associated with certain types of cancers, suggesting its potential as a biomarker or therapeutic target. The functional characterization of KCTD18 through recombinant protein expression techniques allows for the investigation of its biochemical properties, interactions with other proteins, and its role in ion channel modulation. Understanding the biological functions and mechanisms of KCTD18 is vital for elucidating its involvement in health and disease, thereby paving the way for future therapeutic strategies. Moreover, research on KCTD18 can contribute to a deeper understanding of the KCTD protein family, which is still largely underexplored, highlighting its significance in the broader context of cellular regulation and pathology. As such, the recombinant expression of KCTD18 serves as a foundational step in exploring its functional roles, interactions, and potential implications in various medical fields.
