Analytical Data
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Gene name
KCTD18
- Application
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Alternative Names
KCTD18; BTB/POZ domain-containing protein KCTD18
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6PI47
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Expression Region
1-426aa
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AA Sequence
MEGHKAEEEVLDVLRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRDGRLFKYLLDYLHGEVQIPTDEQTRIALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYATKTDGTDAIEKQLGGRIHSKGIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLLGSLRHMAPIRKRRLITFNEADESVNYKTGPKPVRFLGPSTSTQIKVKNSASVTVSPASAIQTSAGATANRFQSGSRRKAAQRSAPSRATALVGTGAPGHPQASPGAASAENGGTHLPPAKVLLSDKKPTPQRVIKLKRTPLCATAPCLPSPTATRQANSLKPLPGEAARALGVRTENGKNKGN
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Molecular Weight
73.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCTD18, a member of the potassium channel tetramerization domain-containing (KCTD) family, has garnered interest in the field of molecular biology due to its potential roles in various physiological and pathological processes. Initially identified as a protein interacting with specific ion channels, recent studies have proposed that KCTD18 is involved in the regulation of cellular signaling pathways, contributing to cellular homeostasis and function. The protein is linked to mechanisms such as cell proliferation, differentiation, and apoptosis, which are crucial in development and disease progression. Furthermore, aberrant expression of KCTD18 has been associated with certain types of cancers, suggesting its potential as a biomarker or therapeutic target. The functional characterization of KCTD18 through recombinant protein expression techniques allows for the investigation of its biochemical properties, interactions with other proteins, and its role in ion channel modulation. Understanding the biological functions and mechanisms of KCTD18 is vital for elucidating its involvement in health and disease, thereby paving the way for future therapeutic strategies. Moreover, research on KCTD18 can contribute to a deeper understanding of the KCTD protein family, which is still largely underexplored, highlighting its significance in the broader context of cellular regulation and pathology. As such, the recombinant expression of KCTD18 serves as a foundational step in exploring its functional roles, interactions, and potential implications in various medical fields.
