Analytical Data
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Gene name
ITGB2
- Application
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Alternative Names
ITGB2;CD18;MFI7;Integrin beta-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P05107
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Expression Region
1-769aa
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AA Sequence
MLGLRPPLLALVGLLSLGCALSQECTKFKVSSCRECIESGPGCTWCQKLN FTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSP QKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLG GDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQP PFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEI GWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFD YPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSS NVVHLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDC DGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCR DQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKD NNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCG GPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNV CECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGL QLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPN IAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWNND NPLFKSATTTVMNPKFAES
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Molecular Weight
111 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ITGB2 (Integrin beta 2) is a crucial subunit of integrin receptors, which play a significant role in cell adhesion, migration, and signaling. Integrins are heterodimeric proteins composed of alpha and beta subunits, and ITGB2 pairs primarily with alpha subunits such as ITGA1, ITGA2, and ITGA3 to form integrin complexes essential for leukocyte adhesion and immune response. Research into ITGB2 has gained momentum due to its implications in various biological processes and diseases. Alterations in ITGB2 expression and function have been associated with several pathologies, including autoimmune diseases, inflammatory disorders, and cancer. The study of ITGB2 also extends to its potential as a therapeutic target, as inhibiting its interactions could modulate immune responses or tumor progression.
Furthermore, the production of recombinant ITGB2 proteins is critical for understanding its structural and functional properties, enabling researchers to investigate its role in integrin signaling pathways. Recombinant ITGB2 can be utilized in binding studies and functional assays to elucidate its interaction with ligands and other integrin subunits. Understanding the dynamics of ITGB2 could provide insights into the development of new strategies for disease intervention, especially in conditions where integrin signaling is dysregulated. Overall, the investigation of ITGB2 and its recombinant forms holds promise for contributing to our understanding of cell biology and potential therapeutic advancements in treating integrin-related diseases.
