Analytical Data
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Gene name
KCNV1
- Application
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Alternative Names
KCNV1; Potassium voltage-gated channel subfamily V member 1; Neuronal potassium channel alpha subunit HNKA; Voltage-gated potassium channel subunit Kv8.1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6PIU1
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Expression Region
1-500aa
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AA Sequence
MPSSGRALLDSPLDSGSLTSLGSSVFCSEGEGEPLALGDCFTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMALMSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDVYARSIMEMLRLKGRERASTRSSGGDDFWF
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Molecular Weight
82.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNV1, a member of the potassium channel family, encodes a voltage-gated potassium ion channel that plays a critical role in maintaining the membrane potential and regulating neuronal excitability. Research into KCNV1 has gained momentum in recent years due to its involvement in various pathological conditions, including epilepsy and other neurological disorders. The dysfunction of this channel can lead to altered neuronal firing patterns and ultimately contribute to the symptoms associated with these diseases. The recombinant expression of KCNV1 protein allows for detailed biophysical studies and functional assays, which are essential for understanding its precise mechanisms of action. By utilizing techniques such as X-ray crystallography and electrophysiology, researchers can investigate the structural and functional properties of KCNV1, paving the way for potential therapeutic interventions. Furthermore, the development of KCNV1-targeted drugs could provide novel treatment options for patients suffering from channelopathies. As such, the study of KCNV1 recombinant protein is not only vital for the elucidation of its biological functions but also for facilitating the discovery of innovative pharmacological strategies to combat associated neurological disorders.
