Analytical Data
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基因名
IP6K2
- Application
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别名
IP6K2;IHPK2;Inositol hexakisphosphate kinase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHH9
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表达区间
1-426aa
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氨基酸序列
MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQ FYETLPAEMRKFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVD NSDCEPKSKLLRWTTNKKHHVLETEKTPKDWVRQHRKEEKMKSHKLEEEF EWLKKSEVLYYTVEKKGNISSQLKHYNPWSMKCHQQQLQRMKENAKHRNQ YKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSA VIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLR RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAE DLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHE GQDAGYIFGLQSLIDIVTEISEESGEHHHHHHGGGLNDIFEAQKIEWHE
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分子量
52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IP6K2 (inositol hexakisphosphate kinase 2) is a pivotal enzyme in the phosphoinositide signaling pathway, playing an essential role in cellular processes such as proliferation, differentiation, and apoptosis. It is involved in the phosphorylation of inositol hexakisphosphate (IP6) into inositol pyrophosphates, which are critical for various cellular functions, including energy metabolism and cell signaling. Recent studies have revealed that IP6K2 is not only important for cellular homeostasis but also participates in the regulation of stress responses and tumorigenesis. Dysregulation of IP6K2 has been implicated in several diseases, including cancer, where altered signaling pathways contribute to uncontrolled cell growth. Consequently, IP6K2 has emerged as a potential therapeutic target, making the understanding of its structure and function increasingly important. Research into recombinant forms of IP6K2 allows for the exploration of its enzymatic activity and interaction with other cellular components. This research can aid in developing small molecule inhibitors or activators that could modulate IP6K2 activity for therapeutic purposes. Investigating the molecular mechanisms of IP6K2 will enhance our understanding of its role in health and disease, potentially leading to novel treatment strategies for cancer and other related conditions. Overall, the study of recombinant IP6K2 not only sheds light on its biological significance but also paves the way for innovative approaches in drug development targeting this key enzyme.
