Analytical Data
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Gene name
IP6K2
- Application
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Alternative Names
IP6K2;IHPK2;Inositol hexakisphosphate kinase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UHH9
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Expression Region
1-426aa
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AA Sequence
MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQ FYETLPAEMRKFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVD NSDCEPKSKLLRWTTNKKHHVLETEKTPKDWVRQHRKEEKMKSHKLEEEF EWLKKSEVLYYTVEKKGNISSQLKHYNPWSMKCHQQQLQRMKENAKHRNQ YKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSA VIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLR RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAE DLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHE GQDAGYIFGLQSLIDIVTEISEESGEHHHHHHGGGLNDIFEAQKIEWHE
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Molecular Weight
52 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IP6K2 (inositol hexakisphosphate kinase 2) is a pivotal enzyme in the phosphoinositide signaling pathway, playing an essential role in cellular processes such as proliferation, differentiation, and apoptosis. It is involved in the phosphorylation of inositol hexakisphosphate (IP6) into inositol pyrophosphates, which are critical for various cellular functions, including energy metabolism and cell signaling. Recent studies have revealed that IP6K2 is not only important for cellular homeostasis but also participates in the regulation of stress responses and tumorigenesis. Dysregulation of IP6K2 has been implicated in several diseases, including cancer, where altered signaling pathways contribute to uncontrolled cell growth. Consequently, IP6K2 has emerged as a potential therapeutic target, making the understanding of its structure and function increasingly important. Research into recombinant forms of IP6K2 allows for the exploration of its enzymatic activity and interaction with other cellular components. This research can aid in developing small molecule inhibitors or activators that could modulate IP6K2 activity for therapeutic purposes. Investigating the molecular mechanisms of IP6K2 will enhance our understanding of its role in health and disease, potentially leading to novel treatment strategies for cancer and other related conditions. Overall, the study of recombinant IP6K2 not only sheds light on its biological significance but also paves the way for innovative approaches in drug development targeting this key enzyme.
