Analytical Data
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基因名
IL6ST
- Application
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别名
IL6ST;Interleukin-6 receptor subunit beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P40189
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表达区间
23-122aa
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氨基酸序列
ELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHF TIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL6ST, also known as the Interleukin-6 signal transducer or gp130, plays a critical role in the signaling pathways of various cytokines, particularly those in the IL-6 family. This protein is essential for mediating the effects of IL-6, IL-11, and other related cytokines, influencing diverse biological processes such as inflammation, immune response, and cell survival. Given its pivotal role in these pathways, dysregulation of IL6ST has been implicated in a range of diseases, including cancers, autoimmune disorders, and chronic inflammatory conditions. Research on IL6ST recombinant proteins has gained momentum as scientists explore their potential therapeutic applications. By generating recombinant IL6ST, researchers aim to better understand its structure-function relationships and its interaction with cytokine receptors. These studies can lead to novel strategies for targeting IL6ST signaling in disease treatment. Furthermore, recombinant IL6ST can be utilized in drug development to enhance the efficacy of therapies that manipulate immune responses. Overall, the study of IL6ST recombinant proteins not only deepens our understanding of cytokine signaling networks but also holds promise for new therapeutic avenues in managing various health conditions.
