Analytical Data
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Gene name
NTMT1
- Application
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Alternative Names
NTMT1；Histone H3-like centromeric Protein A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BV86
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Expression Region
2-223aa
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AA Sequence
TSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR
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Molecular Weight
52.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NTMT1 (N-terminal methyltransferase 1) is a methyltransferase enzyme that plays a crucial role in the post-translational modification of proteins by catalyzing the methylation of the N-terminal amino group of certain proteins. This methylation process is essential for various biological functions, including protein stability, localization, and interactions, thereby influencing cellular signaling pathways and metabolic processes. Dysregulation of NTMT1 has been implicated in a variety of diseases, including cancer and neurodegenerative disorders, as altered N-terminal methylation can affect protein function and contribute to disease progression. The recombinant expression of NTMT1 protein has become a focus of research to better understand its enzymatic properties and the mechanisms by which it modifies target proteins. By studying NTMT1 in vitro, researchers aim to elucidate its substrate specificity, kinetic parameters, and interaction with various protein partners. Additionally, the production of NTMT1 as a recombinant protein is critical for developing potential therapeutic strategies targeting its enzymatic activity, which may offer new avenues for treatment in conditions linked to protein methylation abnormalities. Overall, NTMT1 stands out as a significant protein in cellular regulation, and its study provides insights into the broader implications of protein methylation in health and disease.
