Analytical Data
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Gene name
KCNMB4
- Application
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Alternative Names
BK channel subunit beta 4; BK channel subunit beta-4; BKbeta4; Calcium activated potassium channel beta 4 subunit; Calcium activated potassium channel subfamily M subunit beta 4; Calcium activated potassium channel subunit beta 4; Calcium-activated potassium channel; Calcium-activated potassium channel subunit beta-4; Charybdotoxin receptor subunit beta 4; Charybdotoxin receptor subunit beta-4; Hbeta4; K(VCA)beta 4; K(VCA)beta-4; KCMB4_HUMAN
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86W47
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Expression Region
1-210aa
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AA Sequence
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
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Molecular Weight
48.84 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNMB4, a member of the potassium channel accessory subunit family, plays a crucial role in modulating the properties of large conductance calcium-activated potassium (BK) channels. These channels are key regulators of neuronal excitability, smooth muscle contraction, and cardiovascular function. The KCNMB4 subunit is particularly noteworthy due to its tissue-specific expression and involvement in various physiological processes. The research on KCNMB4 recombinant proteins has gained momentum in recent years, driven by the need to understand its specific role in cellular signaling and its potential implications in diseases such as hypertension and neurodegenerative disorders. By studying the structure-function relationship of KCNMB4, researchers aim to elucidate how this subunit influences channel activity, including its impact on ion permeability and gating mechanisms. Furthermore, the availability of recombinant KCNMB4 proteins enables in-depth biochemical and electrophysiological studies, providing insights into the complex interactions between KCNMB4 and BK channels. This research not only enhances our understanding of potassium channel regulation but also opens avenues for therapeutic interventions targeting the KCNMB4 subunit to treat associated pathologies.
