Analytical Data
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基因名
KCNMB4
- Application
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别名
BK channel subunit beta 4; BK channel subunit beta-4; BKbeta4; Calcium activated potassium channel beta 4 subunit; Calcium activated potassium channel subfamily M subunit beta 4; Calcium activated potassium channel subunit beta 4; Calcium-activated potassium channel; Calcium-activated potassium channel subunit beta-4; Charybdotoxin receptor subunit beta 4; Charybdotoxin receptor subunit beta-4; Hbeta4; K(VCA)beta 4; K(VCA)beta-4; KCMB4_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86W47
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表达区间
1-210aa
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氨基酸序列
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
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分子量
48.84 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNMB4, a member of the potassium channel accessory subunit family, plays a crucial role in modulating the properties of large conductance calcium-activated potassium (BK) channels. These channels are key regulators of neuronal excitability, smooth muscle contraction, and cardiovascular function. The KCNMB4 subunit is particularly noteworthy due to its tissue-specific expression and involvement in various physiological processes. The research on KCNMB4 recombinant proteins has gained momentum in recent years, driven by the need to understand its specific role in cellular signaling and its potential implications in diseases such as hypertension and neurodegenerative disorders. By studying the structure-function relationship of KCNMB4, researchers aim to elucidate how this subunit influences channel activity, including its impact on ion permeability and gating mechanisms. Furthermore, the availability of recombinant KCNMB4 proteins enables in-depth biochemical and electrophysiological studies, providing insights into the complex interactions between KCNMB4 and BK channels. This research not only enhances our understanding of potassium channel regulation but also opens avenues for therapeutic interventions targeting the KCNMB4 subunit to treat associated pathologies.
