Analytical Data
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基因名
OMA1
- Application
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别名
OMA1；MPRP1；Metalloendopeptidase OMA1. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96E52
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表达区间
14-524aa
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氨基酸序列
HVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSF LPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEV TAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAI IVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTH LEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAV KEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLN SVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICP RDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRAS SVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMC NCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIP LTYIVEKRTGS
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分子量
75 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OMA1 is a mitochondria-localized metalloprotease that plays a crucial role in maintaining mitochondrial function and dynamics. Its significance has gained attention due to its involvement in the quality control of mitochondria, particularly under stress conditions. Research indicates that OMA1 participates in the proteolytic regulation of mitochondrial fusion and fission processes, which are essential for mitochondrial morphology and function. The enzyme is also implicated in the activation of the mitochondrial stress response, particularly during instances of oxidative stress or perturbations to mitochondrial homeostasis. Dysregulation of OMA1 has been linked to various pathophysiological conditions, including neurodegenerative diseases, highlighting its potential as a therapeutic target. Moreover, recent studies have suggested that OMA1 functions in the processing of specific mitochondrial proteins, influencing mitophagy and apoptosis pathways. Thus, understanding the molecular mechanisms underlying OMA1 activity and regulation can provide insights into mitochondrial biology and disease states, making it a significant focus in the field of cell biology and biomedicine. Ongoing research aims to elucidate the intricate roles of OMA1 in mitochondrial dynamics, its interactions with other mitochondrial proteins, and its potential as a biomarker or target for therapeutic interventions in mitochondrial-related disorders.
